Acne Drug

Acne Vulgaris

Changes in the pilosebaceous units (skin structures consisting of a hair follicle and the associated subcutaneous gland) result in acne vulgaris. Severe acne is inflammatory, but acne can also manifest in non-inflammatory forms. Acne lesions are pimples, spots or zits. Acne is most common during adolescence, affecting more than affecting more than 85 percent of teenagers, and frequently continues into adulthood. For most people, acne diminishes over time and tends to disappear, or at the very least decrease after the early twenties. There is, however, no way to predict how long acne can take to disappear entirely, and some individuals continue to suffer well into their thirties, forties and beyond. Most commonly, the face and upper neck regions are affected, but there may be acne on the chest, back and shoulders as well. Acne may appear on the upper arms, but lesions found there are often keratosis pilaris, not acne. Typical acne lesions are comedones, inflammatory papules, pustules and nodules. Some of the large nodules are cysts and nodulocystic describes severe cases of inflammatory acne.

Acne Treatment Types

There are many products available for the treatment of acne, many of which are without any scientifically-proven effects. Generally speaking, successful treatments show little improvement within the first two weeks, instead taking a period of approximately three months to improve and start flattening out. Many treatments that promise big improvements within two weeks are likely to be largely disappointing. However, short bursts of cortisone can give very quick results, and other treatments can rapidly improve some active spots, but usually not all active spots. Modes of improvement are not necessarily fully understood but in general treatments are believed to work in at least 4 different ways (with many of the best treatments providing multiple simultaneous effects):
1. normalising shedding into the pore to prevent blockage
2. Killing P. acnes
3. Anti-inflammatory effects
4. Hormonal manipulation.

A combination of treatments can greatly reduce the amount and severity of acne in many cases. Those treatments that are most effective tend to have greater potential for side effects and need a greater degree of monitoring, so a step-wise approach is often taken. Many people consult with doctors when deciding which treatments to use, especially when considering using any treatments in combination.

Isotretinoin

A daily oral intake of vitamin A derivative isotretinoin (marketed as Accutane, Amnesteem, Sotret, Claravis, Clarus) over a period of 4-6 months can cause long-term resolution or reduction of acne. It is believed that isotretinoin works primarily by reducing the secretion of oils from the glands, however some studies suggest that it affects other acne-related factors as well. Isotretinoin has been shown to be very effective in treating severe acne and can either improve or clear well over 80% of patients. The drug has a much longer effect than anti-bacterial treatments and will often cure acne for good. The treatment requires close medical supervision by a dermatologist because the drug has many known side effects (many of which can be severe). About 25% of patients may relapse after one treatment. In those cases, a second treatment for another 4-6 months may be indicated to obtain desired results. It is often recommended that one lets a few months pass between the two treatments, because the condition can actually improve somewhat in the time after stopping the treatment and waiting a few months also gives the body a chance to recover. Occasionally a third or even a fourth course is used, but the benefits are often less substantial. The most common side effects are dry skin and occasional nosebleeds (secondary to dry nasal mucosa). Oral retinoids also often cause an initial flare up of acne within a month or so, which can be severe. There are reports that the drug has damaged the liver of patients. For this reason, it is recommended that patients have blood samples taken and examined before and during treatment. In some cases, treatment is terminated or reduced due to elevated liver enzymes in the blood, which might be related to liver damage. Others claim that the reports of permanent damage to the liver are unsubstantiated, and routine testing is considered unnecessary by some dermatologists. Blood triglycerides also need to be monitored. However, routine testing are part of the official guidelines for the use of the drug in many countries. Some press reports suggest that isotretinoin may cause depression but as of September 2005 there is no agreement in the medical literature as to the risk. The drug also causes birth defects if women become pregnant while taking it or take it while pregnant. For this reason, female patients are required to use two separate forms of birth control or vow abstinence while on the drug. Because of this, the drug is supposed to be given to females as a last resort after milder treatments have proven insufficient. Restrictive rules (see iPledge program) for use were put into force in the USA beginning in March 2006 to prevent misuse, causing occasioned widespread editorial comment. Health Insurance covers some acne treatment

Skin Tag

A skin tag is a common, benign condition that consists of a bit of skin which projects from the surrounding skin and may appear attached to the skin. Skin tags can vary quite a bit in appearance. They may be smooth or irregular, flesh colored or more deeply pigmented, and either simply be raised above the surrounding skin or have a stalk so that the skin tag hangs from the skin. Americans spend billions of dollars each year on skin care products that promise to erase wrinkles, lighten age spots and eliminate itching, flaking or redness. Yet, the simplest and cheapest way to keep skin healthy and young looking is to stay out of the sun. Sunlight is a major cause of the skin changes we think of as aging--changes such as wrinkles, dryness and age spots. The skin does change as it ages. For example, with age, people sweat less, leading to increased skin dryness. As the skin ages, it becomes thinner and loses fat, so it looks less plump and smooth. Underlying structures--veins and bones in particular--become more prominent. Skin can take longer to heal when injured.